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(1) Immunological effects of occupational and environmental fibrous and particulate substances, (2) Establishment of health promoting indoor circumstances
Japan (IFMSA-Japan) - Kawasaki Medical University, Okayama(Kansai area)
Department of Hygiene, Kawasaki MEdsical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan
Takemi Otsuki,MD, PhD, Professor
Takemi Otsuki,MD, PhD, Professor
Type of Research Project
- Basic science
What is the background of the project?
Among the various scientific fields covered in the area of hygiene such as environmental medicine, epidemiology, public health and preventive medicine, we are investigating the immunological effects of fibrous and particulate substances in the environment and work surroundings, such as asbestos fibers and silica particles. In addition to these studies, we have attempted to construct health-promoting living conditions. Thus, in this review we will summarize our investigations regarding the (1) immunological effects of asbestos fibers, (2) immunological effects of silica particles, and (3) construction of a health-promoting living environment. This review article summarizes the 2014 Japanese Society for Hygiene (JSH) Award Lecture of the 85th Annual Meeting of the JSH entitled "Environmental health effects: immunological effects of fibrous and particulate matter and establishment of health-promoting environments" presented by the first author of this manuscript, Prof. Otsuki, Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan, the recipient of the 2014 JSH award. The results of our experiments can be summarized as follows: (1) asbestos fibers reduce anti-tumor immunity, (2) silica particles chronically activate responder and regulatory T cells causing an unbalance of these two populations of T helper cells, which may contribute to the development of autoimmune disorders frequently complicating silicosis, and (3) living conditions to enhance natural killer cell activity were developed, which may promote the prevention of cancers and diminish symptoms of virus infections.
What is the aim of the project?
To know the much more details of immunological effects of fibrous and particulate substances and to build preventive methods, and contribute to the people who suffered with these health disturbances by making early detecting markers from our researches. In addition, improvement of indoor air will support human lives.
What techniques and methods are used?
Molecular biology (PCR< Western blot), cell culture methods, immunological methods using flowcytometry
What is the role of the student?
- The student will mainly observe
What are the tasks expected to be accomplished by the student?
Really not require the tasks. Just, listen what tutor tell, and repeat exactly, thereafter, consider by him/her-self
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
So far, no, but we usualy provide our previous reported manuscrits for better understanding.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Not in particular. Sincere attitude should be there
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- 1) https://www.intechopen.com/online-first/immune-alteration-caused-by-fibrous-and-particulate-environmental-substances Kumagai-Takei N; Lee S; Yoshitome K; Sada N; Nishimura Y; Otsuki T. Immune alteration caused by fibrous and particulate environmental substances. In: Environmental Factors affecting Human Health. ISBN 978-1-78985-528-9 Book edited by: Prof. Ivan Uher DOI: 10.5772/intechopen.86518
- 2) https://www.addgene.org/guides/crispr/ CRISPR Guide from Addgene
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