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Bioeffects of ultrasound energy and_its application for enhancement of drug efficiency
Japan (IFMSA-Japan) - Fukuoka University, Fukuoka
Department of Anatomy, Fukuoka University School of Medicine
Katsuro Tachibana, M.D., Ph.D.
Katsuro Tachibana, M.D., Ph.D.
Type of Research Project
- Basic science
What is the background of the project?
The professor and leader of this project is a well known scientist/physician in the field of therapeutic ultrasound. He is a pioneer in new medical use of ultrasound energy to enhance drug delivery (DDS). The research lab consists of multi-national members who can instruct the students to perform basic experiments. Although this department specializes in basic medicine, 80% of the researchers are medical doctors (MD). The students can also learn how to use sonographic device.
What is the aim of the project?
The aim of the project is to study the bio effect of ultrasound energy by various modalities such as electron microscopy, laser microscopy, functional fluorescent agents, etc. Recent findings at our lab have suggested exciting potential to use ultrasound to enhance drug delivery. Current projects concentrate on development of new methods for gene therapy, thrombolysis, anti-cancer agents. The other major emphasis is the study of the physics related to the above technology. The bio- engineering aspects and bio-materials are also being evaluated at our lab (examples: device, microbubbles, nano-particles that encapsulate and carry drugs).
What techniques and methods are used?
Conventional microscope, Fluorescent microscope, Flow cytometry, Cancer cell culturing techniques, Sonography, MTT Cell Proliferation Assay, Acoustic bioengineering.
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Present results and data at a conference. And the students will acquire basic skills on initial designing of experiments, careful planning (time table, budget, etc), basic knowledge on the subject, data analysis skills , presentation and writing skills.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No theoretical teaching provided
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No specific requirements are needed but the students should have to some extent knowledge concerning basic medicine (cell biology, anatomy, biochemistry, pharmacology, etc).
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Induction of cell- membrane porosity by ultrasound. Lancet. 353; 1409; 1999.
- Induction of Reparative Dentin Formation by Growth/differentiation factor 11 (Gdf11) Employing Ultrasound-Mediated Gene Delivery. Human Gene Therapy 14:591-597; 2003.
- Local delivery of Plasmid DNA into rat carotid artery using ultrasound. Circulation 105; 1233-39. 2002
- Enhancement of fibrinolysis with ultrasound energy. Journal of Vascular Interventional Radiology;3: 299-303;1992
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