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Genetic, Molecular and Pharmacological studies for Childhood Epilepsy
Japan (IFMSA-Japan) - Fukuoka University, Fukuoka
Department of Pediatrics, School of Medicine, Fukuoka University
Shinichi Hirose, MD, PhD
Shinichi Hirose, MD, PhD
Type of Research Project
- Basic science
What is the background of the project?
Epilepsy is a group of disorders characterized by recurrent seizures - paroxysms involving a part of (partial) or the entire body (generalized). Approximately 50 million people worldwide have epilepsy and 0.5 - 1% of children each year are born with some type of epileptic syndrome. This lab studies different types of genetical childhood epilepsies searching for both the cause and a potential treatment for them.
What is the aim of the project?
The aim of the project is to study the unclear molecular pathogenesis of different types of childhood epilepsy (e.g. Dravet Syndrome).
What techniques and methods are used?
To achieve this we use various molecular biology techniques ranging from simple to sophisticated ones like primary or iPS cell culture, DNA sequencing, immunostaining, and handling successfully engineered model animals.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The participants will learn basic lab skills and techniques while experimenting and conducting biological science research and will also acquire knowledge of molecular biology and genetics which is useful for both medical research and in a clinical setting.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Brief theoretical lectures will sometimes be provided by Post-doctors currently working at the laboratory to further increase the student’s understanding of what is being studied and researched extensively here.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge on biology is mandatory and having taken classes of molecular biology is preferable.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Tomonoh Y; Deshimaru M; Araki K; Miyazaki Y; Arasaki T; Tanaka Y; Kitamura H; Mori F; Wakabayashi K; Yamashita S; Saito R; Itoh M; Uchida T; Yamada J; Migita K; Ueno S; Kitaura H; Kakita A; Lossin C; Takano Y; Hirose S. The Kick-In System: A Novel Rapid Knock-In Strategy. PLoS ONE. 2014;9(2):e88549.
- Sasaki M; Ishii A; Saito Y; Morisada N; Iijima K; Takada S; Araki A; Tanabe Y; Arai H; Yamashita S; Ohashi T; Oda Y; Ichiseki H; Hirabayashi S; Yasuhara A; Kawawaki H; Kimura S; Shimono M; Narumiya S; Suzuki M; Yoshida T; Oyazato Y; Tsuneishi S; Ozasa S; Yokochi K; Dejima S; Akiyama T; Kishi N; Kira R; Ikeda T; Oguni H; Zhang B; Tsuji S; Hirose S. Genotype-phenotype correlations in alternating hemiplegia of childhood. Neurology. 2014;82(6):482-90. Epub 2014/01/17.
- Ishii A; Saito Y; Mitsui J; Ishiura H; Yoshimura J; Arai H; Yamashita S; Kimura S; Oguni H; Morishita S; Tsuji S; Sasaki M; Hirose S. Identification of ATP1A3 mutations by exome sequencing as the cause of alternating hemiplegia of childhood in Japanese patients. PLoS ONE. 2013;8(2):e56120. Epub 2013/02/15
- Higurashi N; Uchida T; Lossin C; Misumi Y; Okada Y; Akamatsu W; Imaizumi Y; Zhang B; Nabeshima K; Mori MX; Katsurabayashi S; Shirasaka Y; Okano H; Hirose S. A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain. 2013;6:19. Epub 2013/05/04.
- Hirose S; Scheffer IE; Marini C; De Jonghe P; Andermann E; Goldman AM; Kauffman M; Tan NC; Lowenstein DH; Sisodiya SM; Ottman R; Berkovic SF; Genetics Commission of the International League Against E. SCN1A testing for epilepsy: application in clinical practice. Epilepsia. 2013;54(5):946-52. Epub 2013/04/17
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