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Role of NEG2D ligands and proteasomes in disease pathogenesis
Department of Pathology, Hokkaido University Graduate School of Medicine
Masanori Kasahara, M.D., Ph.D., Professor
Utano Tomaru, M.D., Ph.D., Assistant Professor
Type of Research Project
- Basic science
What is the background of the project?
Natural killer (NK) cells play a critical role in the elimination of virus-infected cells or transformed cells. NKG2D is an activating receptor expressed on the surface of NK cells. It binds to a family of stress-inducible ligands with structural similarity to major histocompatibility complex class I proteins. The proteasome constitutes the central proteolytic component of the highly conserved ubiquitin-proteasome system, which is required for the maintenance and regulation of basic cellular processes, including differentiation, proliferation, cell cycling, gene transcription, apoptosis, and the generation of antigenic peptides presented by MHC class;#8544;#12288;molecules.
What is the aim of the project?
The specific aim of this project is to understand the role of NKG2D ligands and proteasomes in disease pathogenesis.
What techniques and methods are used?
Standard techniques of molecular biology and immunology will be used.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Please ask us
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No specific skills will be required. Prospective applicants should have a basic knowledge of pathology, genetics and immunology as well as a good command of English.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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