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Explore of intracellular transport in the neuron. __Investigation of the pathogenesis of Parkinson disease.
Japan(IFMSA-Japan) - Osaka City University, Osaka(Kansai area)
Department of Genetic Disease Research,Osaka City University Graduate School of Medicine
Shinji Hirotsune M.D. ph.D
Jin Mingyue, Syuhei Chiba, Sakiko Matsumoto
Type of Research Project
- Basic science
What is the background of the project?
(1) MTs serve as tracks for 2 families of motor proteins, kinesins and dyneins, which move toward the plus and minus ends of MTs, respectively, thus facilitating long- range transport within cells. In particular, cytoplasmic dynein is regulated by several multifunctional adaptors, including dynactin, BicD, NDEL1, and LIS1. Thus, we are investigating how these molecules are invloved in the intracellular transport in the neuron. (2) The neuronal protein α-synuclein (αSyn) has been linked to Parkinson’s disease, but how mutant synucleins play a causative role is not clear. We are currently investigating an underlying mechanism by which synuclerin regulates microtubule organiziation.
What is the aim of the project?
Cytoplasmic dynein is regulated by several multifunctional adaptors. In partuclar, mutations of these genes resluts in devastating developmental defect of the brain. Our aim is to uncover the pathogenesis of developmental defect of the brain. (2) Synuclein is broadly expressed in the neuron. Our aim of the project will uncover an underlying mechanism of selective degeneration of dopamine neurons.
What techniques and methods are used?
(1) Making and handling of purified protein. and recombinant proteins. (2) Immunocytochemistry and immunohistochemistry. (3) Electronmicroscopic examination. (4) Investigation of model mouse.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Microscopic examination. Participation to the protein purification. Making recombinant DNA.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
We provide lecture before participation to a project.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge in the molecular biology and basic technique ,including PCR and histology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- Nature Reviews Molecular Cell Biology 14; 713–726 (2013)
- Nature Reviews Molecular Cell Biology 10; 682-696 (2009)
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