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Molecular mechanism of the development of organs
University of Tsukuba
Department of Anatomy and Embryology Majors of Medical Sciences
Satoru Takahashi, M.D., Ph.D.
Michito Hamada, Ph.D, Takashi Kudo , Ph.D.
Type of Research Project
- Basic science
What is the background of the project?
Large Maf transcription factors are important for development of many cells, for example pancreatic endocrine cells, macrophage and podocytes of kidney. We are trying to investigate in vivo functions of Large Maf transcription factors by using genetically modified mice.
What is the aim of the project?
The aim of the project is to study the molecular mechanism of how neural systems are formed. To this end, the genes and proteins involved in neural development are examined using molecular biological and histological techniques. The animals used are genetically manipulated or mutant mouse and zebrafish embryos. The techniques and methods used are RT-PCR (reverse transcription-polymerase chain reaction), Northern blot, Western blot, in situ hybridization, immunohistochemistry. Short lectures on the theoretical background concerning the experimental procedures will be provided if necessary. The students should learn the principles of experimental procedures and perform all the Further information; Cell vol. 87, pp. 175-185, 1996. Current Biology vol. 13, pp. 73-77, 2003. Scientific Reports vol. 7, pp. 13847, 2017 Brain Research vol. 1710, 209-219, 2019.
What techniques and methods are used?
Generation method of genetically modified mice by using CRISPR/Cas9 and histological analysis of mouse and Moleculer Biology techniques.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
We ask students to join our research team and do some part of our research.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Every Monday, we have progress meeting and journal club, which provide you basic knowlleges of reseach.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of molecular biology, animal experiments, histological analysis, gene engineering.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Hamada M; Nakamura M; Tran MT; Moriguchi T; Hong C; Ohsumi T; Dinh TT; Kusakabe M; Hattori M; Katsumata T; Arai S; Nakashima K; Kudo T; Kuroda E; Wu CH; Kao PH; Sakai M; Shimano H; Miyazaki T; Tontonz P; Takahashi S. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 5; 3147; 2014.
- Morito N; Yoh K; Ojima M; Okamura M; Nakamura M; Hamada M; Yamagata K; Takahashi S. Mafb plays a protective role in diabetic nephropathy through slit- diaphragm proteins; anti-oxidative enzymes and Notch pathways of podocytes. J Am Soc Nephrol. 25; 2546-2557; 2014.
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