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Calcium oxalate crystallization index (COCI) : a novel method for distinguishing nephrolithiasis patients from healthy subjects
Thailand (IFMSA-Thailand) - Faculty of Medicine, Chulalongkorn University, Bangkok
Department of Biochemistry, Chulalongkorn University
Assist. Prof. Dr. Pisit Prapunwattana
Assist. Prof. Dr. Chanchai Boonla
Type of Research Project
- Basic science
What is the background of the project?
Kidney stone disease or nephrolithiasis is a common health problem around the globe. Although, the mechanism of stone formation is largely known and there is no currently screening index being used. The study focuses on Calcium Oxalate crystallization index (COCI) as an alternative method for distinguishing nephrolithiasis patients from healthy individuals based on the urinary crystallization capability. By applying it to the suspected patients, we can study the sensitivity and specificity of the test. The effect of urine volume, oxalate, phosphate, citrate, potassium, and sodium on COCI values was investigated.
What is the aim of the project?
This research is aimed to study the validity of using Calcium Oxalate crystallization index (COCI) applying to the populations and patients in King Chulalongkorn Memorial Hospital.
What techniques and methods are used?
Molecular biology technique Epidemiologic studies technique
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The students will allowed to use a high-technology labaratory instruments to study validity of using Calcium Oxalate crystallization index (COCI) applying to the populations and patients in King Chulalongkorn Memorial Hospital, using the epidemiologic technique to calculate the statistical data, and learning the clinical signs and symptoms of nephrolithiasis patients.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Fundamental knowledge of biochemistry. Students must attend at least 80% of laboratory sessions.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
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