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Brain Iron and Neuroinflammation
Thailand (IFMSA-Thailand) - Faculty of Medicine, Chulalongkorn University, Bangkok
Department of Anatomy, Faculty of Medicine, Chulalongkorn University
Prof. Dr. Apiwat Mutirangura
Assoc. Prof. Dr. Poonlarp Cheepsunthorn
Type of Research Project
- Basic science
What is the background of the project?
Neuroinflammation is a process that can cause neurodegeneration through the loss of neuronal structure and function. The aim of the project is to explore the inflammatory components of many neurodegenerative diseases including Alzheimer's disease. A notable compound is beta amyloid peptides (AB1-42) which contributes to the presence of amyloid plaques in the brains of Alzheimer's patients. When microglial cells are induced by beta amyloid peptides, they release proteins to regulate gene expression, signal transduction, immune responses, cytoskeletal structural integrity, and more. Some of the proteins released may be associated with mild cognitive impairment (MCI). Techniques used in this project are Reverse Transcription Polymerase Chain Reaction (RT-PCR), Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and cell culture.
What is the aim of the project?
To explores the inflammatory components of many neurodegenerative diseases including Alzheimer's disease.
What techniques and methods are used?
Real Time PCR and cell culture
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Students are expected to attend laboratory sessions, follow the tutor and staffs' instructions dutifully.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic laboratory skills are required; able to pipette. Knowledge: Students should have some backgrounds on glial cells in the CNS and brain inflammatory reactions.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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