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Effect of aging and degenerative diseases of the central nervous system on the extracellular space diffusion parameters and extracellular matrix
Czech Republic (IFMSA CZ) - Charles University, 2nd Medical Faculty, Prague
Department of Neuroscience, Charles University, 2nd Medical Faculty
Assoc. Prof. Lydia Vargova, MD., Ph.D.
Michal Cicanic, MD.
Type of Research Project
- Basic science
What is the background of the project?
Students will study the effect aging and degenerative diseases. Project will lead to better understanding of pathogenic mechanisms with possible impact on diagnosis, evaluation of treatment and development of new drugs for causal treatment.
What is the aim of the project?
Students will study the effect aging and degenerative diseases (like Alzheimer´s) on tissue properties, extracellular space diffusion parameters and quantitative and qualitative changes of extracellular matrix.
What techniques and methods are used?
Students will study changes in ECS volume fraction and the decrease in the apparent diffusion coefficients (ADC) of neuroactive substances diffusing in the ECS as well as the ADC of water.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Role of the student is working under the supervision of the researcher on the project. In case of active participation in the research project SCORE student will be coauthor of a poster or paper. The student will have an opportunity to learn manufacturing of ion-selective electrode for measurements of ion concentration in living tissue and basic skills in unique real-time iontophoretic technique for measurements of diffusion parameters of the extracellular space. Apart from practical skills, students will acquire theoretical knowledge about changes of extracellular diffusion properties in various models of human brain pathologies, extrasynaptic transmission, neuron-glia communication and extracellular matrix.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Internal seminars (weakly) focused on the topic theory and interpretation of experimental results Final presentation of the results by SCORE student, internal Seminar
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic neurolophysiological skills are required.
Students considering participating in the project are supposed to look through the following article:
? Sykova; E, Nicholson C. (2008), Diffusion in brain extracellular space, Physiol Rev. 2008 Oct;88(4):1277-340. doi: 10.1152/physrev.00027.2007. Review. For education process will be necessary special clothes: - White medical shoes - White pants - White coat + white T-shirt
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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