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Spectral karyotype (SKY) in acute myeloid leukemia.
Università degli studi di Chieti
prof. Giandomenico Palka
prof. Giuseppe Calabrese
Type of Research Project
- Basic science
What is the background of the project?
In acute myeloid leukaemia (AML) conventional cytogenetics is unable to establish a karyotype in 20-40% of patients.
What is the aim of the project?
We will analyse by spectral karyotype (SKY) patients suffering from AML who had a highly rearranged karyotype, i.e. over two breakpoints or at least three rearranged chromosomes, as determined by conventional cytogenetics.In patients with highly rearranged karyotypes SKY analysis allowed to classify all undefined, or defined abnormal chromosomes. FISH analysis will carry out to confirm SKY results and to further characterise the rearrangements disclosed involvement of different genes. In conclusion SKY analysis in AML patients provide a relevant contribution to the characterisation of highly rearranged karyotypes unraveling cryptic specific translocation and biological mechanism of the disease.
What techniques and methods are used?
FISH, SKY Analysis
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
the student will have a role as participant in all the technical phases concerning the project. In particular the student will participate in planning experiments and in evaluating the results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of biochemistry and human genetic.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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