Projects
Name
Roles of Cl- homeostasis in normal and pathological brain development
University
Japan (IFMSA-Japan) - Hamamatsu University School of Medicine, Hamamatsu
Domain
Physiology
Departement
Department of Neurophysiology, Hamamatsu University School of Med.
Head
Atsuo Fukuda, M.D., Ph.D., Professor and Chairman, Department of Neurophysiology
Tutor
Tenpei Akita, M.D. Ph.D, Miho Watanabe, M.D. Ph.D, Masaru Ishibashi,M.D. Ph.D, Tyaning Wang, Ph.D, Adya Saran Shinha
Languages
English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No Yes Yes Yes No No No No
Type of Research Project
- Basic science
What is the background of the project?
GABA is the most principal inhibitory neurotransmitter in the brain, for which GABAA receptor-mediated actions depend on Cl- gradient. Therefore, Cl- homeostatic changes during development and pathogenesis could play pivotal roles in neural network formation and function.
What is the aim of the project?
Investigaing migration and synaptogenesis of neocortical GABAergic and glutamatergic neurons: roles of Cl- homeostasis and influence of maternal stress or perinatal injury.
What techniques and methods are used?
Confocal imaging, patch-clamp recording, single cell RT-PCR, in vivo electroporation, siRNA, maternal stress or focal freeze-lesion model.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Please inquire us via your NORE
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Please inquire us via your NORE
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic science of Neuroscience, Physiology and Biochemistry. Experience of fundamental laboratory practice is preferred.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
Articles
- http://www.hama-med.ac.jp/education/fac-med/dept/neurophysiology/index.html