Projects
Name
Molecular epidemiology of human common cancers
University
Japan (IFMSA-Japan) - Hamamatsu University School of Medicine, Hamamatsu
Domain
Pathology
Departement
Department of Tumor Pathology, Hamamatsu University School of Medicine
Head
Haruhiko Sugimura, M.D., Ph.D., Professor and Chairman, Department of Pathology
Tutor
Shinmura, MD.PhD, Tomoaki Kahyo, Hidetaka Yamada(PhD), Hong Tao, Nobuya Kurabe(PhD)
Languages
English, Japanese, and Chinese
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No Yes No No Yes Yes Yes Yes No Yes Yes No
Type of Research Project
- Basic science
What is the background of the project?
The origins of human common cancers are largely from environmental according to huge amount of epidemiological and experimental data. On the other hand, genetic origins of human cancer draw a lot of attention of both researchers and laymen. Exactly, most human cancers occur through interplay of individual genetic predisposition and exposure to environmental chemicals. In this department, evaluations of genetic polymorphisms of the genes involved in DNA repair, carcinogen metabolism, unstable repetitive sequence in terms of individual risk to gastric, colon, esophageal, and lung carcinoma especially including environmental factors such as smoking, diet, and other life styles are done. To accomplish this purpose, we pick up the candidate gene polymorphisms in silico, verify the biological and functional study about the corresponding variation of genes, and further search for somatic change in naturally occurring cancer tissues. The genes we handled these days are Eph-Ephrin families, OGG1, MYH, KLK12, SGOL1, NEIL1, NTH1, PD-L1,PD-L2, and others and this list is continuously becoming longer. Which genes you will juggle depend on how far we are on the way to the goal in each gene when you join us. These days, we set up microarray analysis system for more comprehensive study of the tumor genome, GWAS study, and DNA adductomics study. Knowledge of applied mathematics (Bioinformatics and programming) would be welcome.
What is the aim of the project?
Evaluating genetic polymorphisms of the genes involved in DNA repair, carcinogen metabolism, unstable repetitive sequence in terms of individual risk to gastric, colon, esophageal, and lung carcinoma especially including environmental factors such as smoking, diet, and other life styles.
What techniques and methods are used?
Please inquire us via your NORE
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Please inquire us via your NORE
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Please inquire us via your NORE
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of Molecular Biology, Pathology, Epidemiology, and Biochemistry. Experience of a fundamental laboratory practice is preferred.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
Articles
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