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Effects of anti-tumor chemical, cucurbitacins on tumor cells
Japan (IFMSA-Japan) - University of Occupational & Environmental Health Medical, Fukuoka
Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Japan 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan
Tamotsu Kanazawa, MD, PhD, professor
Yasuhiro Yoshida, PhD, Associate professor
Type of Research Project
- Basic science
What is the background of the project?
ATL is an aggressive and malignant blood disease. There are many ATL patients in the Kyushu area of Japan who have a very poor prognosis even with intensive chemotherapy, owing to rapid disease progression and frequent infectious complications. Several drugs including synthetic glucocorticoids are used in chemotherapy; however, the treatment is not completely effective due to the development of drug resistance.
What is the aim of the project?
Please inquire us via your NORE
What techniques and methods are used?
Cell culture, microscope, ELISA
What is the role of the student?
- The student will mainly observe
What are the tasks expected to be accomplished by the student?
Students observe the demonstration of our graduate student, and learn way of the cell culture to be it first. Additionally, students learn how to use device and have analyze anti- cancer effects.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Journal club (introducing an interesting paper)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of biochemistry, molecular biology and immunology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system - Students in biomedical fields
- 1. HTLV-I associated post-transplant lymphoproliferative disorder following virus transmission from recipient to donor cells. Kitamura N; Nakanishi T; Yoshida Y; Higashi T; Tsukada J. Blood. 2017 May 9.
- 2. Relationship between triterpenoid anticancer drug resistance; autophagy; and caspase-1 in adult T-cell leukemia. Nakanishi T; Song Y; He C; Wang D; Morita K; Tsukada J; Kanazawa T; Yoshida Y. PeerJ. 2016 May 12;4:e2026.
- 3. Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells. Nakanishi T; Song Y; He C; Wang D; Morita K; Tsukada J; Kanazawa T; Yoshida Y. Med Oncol. 2016 Apr;33(4):30.
- 4. Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T-cell leukemia. Ding N; Yamashita U; Matsuoka H; Sugiura T; Tsukada J; Noguchi J; Yoshida Y. Cancer. 2011 Jun 15;117(12):2735-46.
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