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Reproductive Health and Mechanisms of Hormone Action
Finland (FiMSIC) - University of Turku, Turku
Department of Physiology
Prof. Jorma Toppari
Jorma Toppari, Matti Poutanen, Nafis Rahman
Type of Research Project
- Basic science
What is the background of the project?
Our research focus is in reproductive health. We study the genetic and environmental factors that affect development and function of the testis. Disorders of testicular development can cause maldescent of the testis (cryptrorchidism), hypospadias, impaired spermatogenesis and testicular cancer. We investigate both molecular mechanisms and clinical findings by exploring the regulation of spermatogenesis, semen quality, pubertal development (JT) and characterizing the factors involved in the regulation of male germ cell differentiation, male fertility, gene control mechanisms in male germ line, especially on non-coding RNAs and posttranscriptional RNA regulation (NK). In parallel projects in the department, the focus is on G-coupled receptor signaling and cancer (IH); hormone-dependent cancers and their novel treatment strategies (NR); endometriosis & local steroid metabolism, pre-receptor regulation of nuclear receptor signaling especially by Hydroxysteroid (17beta) dehydrogenases (HSD17Bs) (MP); molecular mechanisms of thyroid diseases and thyroid cancer (Kero) . The projects are led by Jorma Toppari (JT), Matti Poutanen (MP), Ilpo Huhtaniemi (IH), Noora Kotaja (NK), Nafis Rahman (NR) and Jukka Kero (JK). Their research groups include about 30 scientists who are at different levels of their scientific careers. The research environment is highly international with researchers from 10 different countries.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge on cell and molecular biology is highly appreciated. The daily language in the laboratory is English, so good skills in English is essential.
Are there any legal limitations in the student’s involvement
NO MRSA negative certificate needed for this project
Type of students accepted
This project accepts: - Medical students
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