Projects
Name
Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 activation signaling by TNF-alpha via NF-KB
University
Taiwan (FMS-Taiwan) - Chung Shan Medical University, Taichung
Domain
Immunology
Departement
Chung-Shan Medical University, Institute of Immunology, R.1004, NO.110, sec.1, Chien-Kuo N
Head
Guang-Yaw Liu
Tutor
Guang-Yaw Liu
Languages
English
Duration
8 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes No No No No
Type of Research Project
- Basic science
What is the background of the project?
I. The aim of this project is to find out why ornithine decarboxylase(ODC) results in immature activity and deprived differentiation of leukemia, which results in abnormal proliferation and differentiation of myeloid progenitor cells. Our hypothesis is that ODC interferes with macrophage-like differentiation and matrix metalloproteinase-9(MMP-9) activation signaling by tumor necrosis factor alpha(TNF-alpha) via NF-alpha. Therefore, we aim to accomplish the following studies to elucidate the molecular mechanisms about how ODC interferes with the MMP-9 expression on macrophage-like differentiation. 1.The roles of polyamine biosynthesis pathway in TPA-induced macrophage-like differentiation in HL-60 and U-937 cells 2.The roles of ODC in MMP-9 expression and activity during macrophage-like differentiation
What is the aim of the project?
not provided
What techniques and methods are used?
not provided
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
not provided
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
0
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student needed to know the basic knowledge concerning about Cell Biology, Biochemistry, Immunology and Molecular Biology.
Are there any legal limitations in the student’s involvement
No
Hours
8
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles
- NONE