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Hemorheological factors and platelet aggregation in vascular diseases
Hungary(HuMSIRC)-University of Pecs,Pecs
Division of Cardiology, First Department of Medicine
Prof. Kalman Toth MD, PhD, ScD
Katalin Koltai MD, Gabor Kesmarky MD, PhD, Prof. Kalman Toth MD, PhD, ScD
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Patients with cardio-, cerebro- and peripheral vascular diseases are involved in our studies. The following hemorheological parameters are detected: hematocrit in microhematocrit centrifuge, plasma and whole blood viscosity in capillary viscosimeter, red blood cell aggregation in optical erythrocyte aggregometer, red blood cell deformability in erythrocyte filtrometer. The effectiveness of antiplatelet medication is measured as in vitro platelet aggregability to several stimulators in optical platelet aggregometer. Endothelial dysfunction is investigated through von Willebrand factor activity by ELISA.
Free radical scavenger and antiplatelet activity of drugs and experimental agents are studied in in vitro filtration and platelet aggregation models.
Purpose of the project: Investigation of the hemorheological factors, platelet aggregation and the effectiveness of platelet inhibitors in patients with cardiovascular and cerebrovascular diseases.
What is the aim of the project?
Purpose of the project: Investigation of the hemorheological factors, platelet aggregation and the effectiveness of platelet inhibitors in patients with cardiovascular and cerebrovascular diseases
What techniques and methods are used?
optical platelet aggregometer, ELISA
What is the role of the student?
What are the tasks expected to be accomplished by the student?
basic lab work
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Completed 5th semester at a Medical School. Completed Biochemistry, Cell- and Molecular Biology, Physiology, Pathophysiology final exams. Motivation. Curriculum vitae, reference letter from the local
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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