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Oxidative stress in chronic renal diseases and diabetes mellitus
Hungary(HuMSIRC)-University of Pecs,Pecs
Second Department of Medicine and Nephrological Center
Prof. Judit Nagy MD, PhD, DSc
Istvan Wittmann MD, PhD
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Chronic renal diseases (CRD) show a progressive nature, which leads to the development of end-stage renal failure. In CRD, increased oxidative stress and decreased nitrogen monoxide (NO) production play a pivotal role in the deterioration of kidney function.
Oxidative stress enhances non-enzymatic glycation, a progress leading to the formation of advanced glycation end-products (AGEs). Accumulation of AGEs may be in part responsible for the development of diabetic complications.
Both oxidative stress and AGEs interfere with NO production, which may be an important factor influencing the progression of renal disease especially in diabetic nephropathy.
Purpose of the project: To study the factors influencing NO production and to reveal the causes of increased oxidative stress in kidney disease and in diabetes mellitus by means of experimental and clinical investigations.
What is the aim of the project?
To study the factors influencing NO production and to reveal the causes of increased oxidative stress in kidney disease and in diabetes mellitus by means of experimental and clinical investigations.
What techniques and methods are used?
molecular cell biology techniques
What is the role of the student?
What are the tasks expected to be accomplished by the student?
basic lab work
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Curriculum Vitae, reference letter.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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