The role of PEA-15 on tumorigenesis of pleural malignant mesothelium
Japan(IFMSA-Japan) - Yamaguchi University, Yamaguchi
Department of Systems Biochemistry in Pathology and Regeneration
Dr. Takao Kitagawa
Dr. Yasuhiro Kuramitsu
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
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Type of Research Project
- Basic science
What is the background of the project?
Proteomics is now a generally accepted method to analyze protein epression and cellular processes at the molecular level. The combination of two-dimensional gel electrophoresis(2-DE) with tandemmass spectrometry(LC-MS/MS) is one of the most powerful tools for profiling the proteome of human diseases, This technique stimulated our interest to obserbe the differences in total protein expression between malignant pleural mesothlioma(MPM) cells and pleural mesothelial cells. Malignant mesothelioma is a malignant neoplasm srising from mesothelial cells existing in pleura, pericardium, peritoneum, etc. Although patients with MPM show symptoms, including breathessness, coughing,weight loss, chest pain, etc. It is difficult to identify a crucial symptom. Therefore, early detection of this tumor is very difficult. And since there is no standard curative therapy for the malignancy, combined therapies of chemotherapy, radiotherapy and surgical resection are being administered. The incidence of MPM is increasing worldwide, and many patients can not survive more than one year after diagnosis. MPM is an asbestos-related disease, and it is believed that the incidence is closely related to the amount and time of exposure to asbestos. Since the latency period after exposure to asbestos is very long, the incidence may increase over the next two decades.
What is the aim of the project?
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What techniques and methods are used?
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What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
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Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
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What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
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Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
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