Molecular biology of nuclear receptors and molecular pathophysiology of metabolic diseases and cancers.
Nihon University
Division of Biochemistry, Department of Biomedical Sciences, Nihon University
Makoto Makishima, M.D., PhD, Professor and Chairman
Makoto Makishima, M.D., PhD, Professor and Chairman
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes Yes Yes Yes No
Type of Research Project
- Basic science
What is the background of the project?
We are investigating the molecular mechanisms of dynamic control of cellular metabolism. Nuclear receptors play important roles in the regulation of metabolism as transcription factors that sense metabolic environments and regulate gene expression. To elucidate such regulation mechanisms is also important in investigation of molecular pathophysiology of human diseases such as metabolic disorders and cancers. We hope this project will help students have more curiosity in science and acquire abilities to solve questions in logical and scientific process.
What is the aim of the project?
To understand the molecular mechanisms of receptors systems controlling extracellular and intracellular metabolic environment and to improve the ability of research to investigate pathophysiology of the related disorders.
What techniques and methods are used?
plasmid construction, transfection to cells, luciferase reporter assay, PCR, etc
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
Carry out construction, transfection to cells, luciferase reporter assay, PCR, etc). Analyze changes of gene expression and metabolism in cultivated cells or experimental animals. Give presentation about the results, discuss with your tutor and lab members, and write papers in English based on your results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The basic knowledge of molecular biology and biochemistry.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
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