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Croatia (CroMSIC) - Josip Juraj Strossmayer University of Osijek, Osijek
Department of Urology
Josip Galic MD, PhD
Hrvoje Kuvezdic MD; Damir Prlic MD
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Urolithiasis is one of the leading social and economical problems of modern society. It is estimated that in developed countries, 10% of males and 4 % of females between 30 and 50 years of age have urinary tract stone disease. The recurrence rate with no treatment is 75% at 15 years. Urinary supersaturation and lack of inhibitors of crystallization in urine are considered important factors in pathogenesis of urolithiasis. Hypothesis and aim: Toxic effect of calcium oxalate is caused by free radicals inducing injury of renal cells, crystal retention and stone formation. Antioxidants inhibit lipid peroxidation and oxidative injury thus inhibiting crystal-cell interaction and decreasing number of injured renal cells in cell cultures. In patients, those same antioxidants would decrease number of apoptotic cells in urine and there would be no cellular debris for crystal nucleation. Aim of this research is to determine toxic effect of oxalate in cell cultures, and to compare antioxidants effect intensity in MDCK cell cultures with effect intensity of antioxidants on reccurence rate in patients with urolithiasis. Conducting experiments: We will determine toxic effect of oxalates in canine renal cell cultures and potential of antioxidants to inhibit crystal-cell interaction (vitamin E, green tea, L-arginin). Furthermore, antioxidants will be also tested on urolithiasis patients with increased number of uroepithelial cells in urine, and their urine will be compared with urines of patients that were given placebo and healthy control groups. Uroepithelial cells in urine, inhibitory potential of urine, antioxidative status and oxalate concentration in urine will be followed in this research. Expected results: Oxalate toxicity on renal epithel is time and dose dependant. With the addition of antioxidants in renal cell culture with the presence of calcium oxalate, renal cell injury and apoptose will be decreased.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
White coat, stethoscope
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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