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Myocardial contractility during physiological and pathophysiological conditions
Hungary(HuMSIRC)-University of Debrecen, Debrecen
Cardiology, University of Debrecen, Medical and Health Science Center, Medical School
Prof. Dr. I. Edes
Prof. Dr. I. Edes, Dr. Z. Papp
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Pathological changes of contractile properties during
various heart diseases form the basis of diminished pump
function of the human heart. Alterations leading to
contractile malfunction are investigated using biochemical,
cellular physiological and isotope techniques. We are
particularly interested to see the molecular correlates
(e.g. phosphorylation, proteolytic degradation, altered
gene expression) of ischemic/reperfused myocardium and
heart failure. Moreover, characterization of novel
inotropic agents (e.g. calcium sensitizers) are carried out
under experimental conditions.
What is the aim of the project?
We are particularly interested to see the molecular correlates (e.g. phosphorylation, proteolytic degradation, altered gene expression) of ischemic/reperfused myocardium and heart failure.
What techniques and methods are used?
biochemical, cellular physiological and isotope techniques.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
basic lab work
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Experience in cardiac physiology and biochemistry
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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