The effect of IL-12 and/or IL-15 on the cell functions of umbilical cord or adult peripheral blood NK or T lymphocytes
Taiwan (FMS-Taiwan) - Chang Gung University, Chinese Dpt, Taipei
Microbiology Division of the Institute of Basic Biology
Professor Yi-Ywan Margaret Chen
Prof. Ming-Ling Kuo, PhD.
English or Chinese
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No Yes Yes Yes No No Yes
Type of Research Project
- Basic science
What is the background of the project?
Cytokines IL-12 and/or IL-15 have high potential to modulate the activity and apoptosis of umbilical cord blood (CB) NK and T lymphocytes. This project will analyze the change and mechanisms of maturation, activation, cytotoxicity, and apoptosis from cytokine-treated CB NK or T cells. The interaction of immuno-suppressive agents and IL-5 on T cells will also be analyzed. The responses of adult peripheral blood cells to cytokines will be determined in this project. The results can be applied to improve the usage of CB as an alternative source to bone marrow for immune reconstitution or NK cell-based therapies for malignancies.
What is the aim of the project?
To determine whether IL-12 and/or IL-15 can be used as adjuvant for cord blood-based stem cell transplantation.
What techniques and methods are used?
Cell culture, flow cytometry, ELISA, apoptosis analyses
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
not provided
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Duration of the project: 4-6 weeks Further information from:
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)