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Molecular and pathological analysis of human cancers
Laboratory of Molecular Cellular Pathology Hokkaido University Graduate School of Medici
Nobuya Tanaka MD, Ph.D
Type of Research Project
- Basic science
What is the background of the project?
Human cancers have been known to be the results of the accumulation of several genetical mutations of genes which are involved in the regulation of cell proliferation and motility. However, the precise mechanism of the generation of malignant transformation of cells is still under the investigation. We are now using several approach to understand the mechanism of human cancer cell growth and invasion, and final aims are the establishment of new criteria of molecular pathophysiological analysis of human cancer predicting the prognosis, and pointing the direction of the therapies.
What is the aim of the project?
Several projects are going on in our lab; 1) To understand the human cancer, autopsy study was performed in the affiliated hospital of Hokkaido University, and students are involved. 2) Pathologically, we have been trying to establish diagnostic marker of malignant tumors. We are focusing on the discrimination of adenoma vs adenocarcinoma/ astrocytoma vs glioblastoma by using surgically rejected specimens. 3) Role for the signaling adaptor protein CRK in human cancer development has been analyzed. Targets of CRK such as C3G and Dock180 those are activator for small GTPases, were originally identified in our laboratory, and currently precise role in cell attachment and motility have been analyzed. 4) Using siRNA, FRET (fluorescence energy transfer) technique, involvement of above proteins in cell invasion have been analyzed.
What techniques and methods are used?
siRNA, FRET (fluorescence energy transfer) etc
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Please ask us
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes if needed
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of molecular biology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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